There are two main types of triggers, Polling (scheduled), and Instant (webhooks). Polling triggers can only run on a schedule. Instant triggers can be run as soon as data is received by the webhook.
Polling means Make checks external service for changes (pull changes to Make).
Webhook (instant) triggers means external service calls Make when there are new changes (push changes to Make).
To find out more on the different types of Trigger modules, see refer to Types of Modules and Webhooks sections of the Make help center.
The trigger module you are using is basically a scheduled API request that Make has to occasionally “call” to fetch the latest changes/items. This is called polling. Polling modules run on a set schedule. You do not need to click Run Once on the scenario, just leave it switched on and it will run at your set schedule (by default 15 mins).
That’s because the Twitter API doesn’t have a webhook option for normal Twitter accounts. Therefore the trigger modules you see on automation platforms like Make and Zapier have to pull new information.